Upper Midwest Environmental Sciences Center
Chronic Toxicity of Diphenhydramine Hydrochloride and Erythromycin Thiocyanate to Daphnia, Daphnia magna, in a Continuous Exposure Test System
Meinertz, J.R., T.M. Schreier, J.A. Bernardy and J.L. Franz, 2010, Chronic Toxicity of Diphenhydramine Hydrochloride and Erythromycin Thiocyanate to Daphnia, Daphnia magna, in a Continuous Exposure Test System.: Bull Environ Comtam Toxicol., v. 85, i. 5, p 447-451. DOI 10.1007/x00128-010-0117-7.
Diphenhydramine hydrochloride (DH; Benadryl™, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 μg/L for 21 days or to ET concentrations about 40 times the maximum reported environmental concentration of 6 μg/L for 21 days did not significantly impact D. magna survival and production. In this study the no observable effect concentration for DH was 0.12 μg/L and for ET was 248 μg/L.
Toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia - Toxicity of pharmaceutical compounds to an aquatic invertebrate